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Welcome to the Villapol Lab
The Brain Periphery Research Lab’s focus is the pursuit of novel neurorestorative treatments for debilitating brain injuries to open the door to alternative therapies that repair the damaged brain through the periphery.
Brain damage: excitotoxicity, cerebral ischemia, stroke, traumatic brain injury, neonatal and adult.
Neuroinflammation: microglia activation, astrogliosis, cytokines, oxidative stress, gliosis, sex-differences, trauma, macrophages, cerebral blood flow, cerebral edema, hypertension, vasculature, glial scar, TGFbeta, smad3, NOS
Neurodegeneration and neurogenesis: apoptosis, necrosis, neurorestoration, neuronal injury, proliferation, oligodendrocytes, caspase-3, PPARgamma.
Neuroprotection and neurorestauration: angiotensin receptor blockers, melatonin, ApoE genotype, sartans, inhaled nitric oxide, candesartan, telmisartan, antisense therapy.
Brain-periphery axis: hepatic inflammation, acute phase proteins, serum amyloid A, systemic inflammation, brain-liver axis, brain-gut axis, microbiome, Brain-Speen axis, Brain-Kidney axis.
Sonia Villapol, Ph.D.
I am an Assistant Professor of Neurosurgery at the Institute for Academic Medicine (IAM), Center for Neuroregeneration, Houston Methodist Research Institute (Houston, TX); and Assistant Professor of Neuroscience in Neurological Surgery at Weill Cornell Medical College, NY.
My scientific research has focused on elucidating the basic mechanisms and processes that occur after different types of brain injuries, including apoptosis, inflammation, neurogenesis or glial activation. My future research plan is fueled by my motivation of investigating the distinct, intricate aspects of the contribution of peripheral signals and microbiome to brain pathology.
Areas of expertise:
- Cerebral ischemia and traumatic brain injury
- Neuroinflammation and neurodegeneration
- Sex and gender differences in response to brain damage
- Brain-Liver axis ~ Brain-gut-microbiome axis
- Glia activation
- Neuroprotection and Neurorestoration