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Welcome to the Villapol Lab
Villapol lab’s focus is the pursuit of novel neurorestorative treatments for debilitating brain injuries to open the door to alternative therapies that repair the damaged brain through the periphery.
Our first MICROBIOME study “Traumatic brain injury in mice induces acute bacterial dysbiosis within the fecal microbiome”, was published in Frontiers in Immunology.
Dr. Villapol was invited to give a seminar at @VCU Department of Anatomy and #Neurobiology, Dr. Andrew Ottens. Thanks faculty, Ph.D. candidates, and Dr. Povlishock for your hospitality!! #Neurotrauma #TBI #proteomics #brainInjury #Neuroinflammation #Glia
Shashi Krishnamurthy presented a poster on Mission Connect Meeting, Houston, Nov 30.
Brain damage: excitotoxicity, cerebral ischemia, stroke, traumatic brain injury, neonatal and adult.
Neuroinflammation: microglia activation, astrogliosis, cytokines, oxidative stress, gliosis, sex-differences, trauma, macrophages, cerebral blood flow, cerebral edema, hypertension, vasculature, glial scar, TGFbeta, smad3, NOS
Neurodegeneration and neurogenesis: apoptosis, necrosis, neurorestoration, neuronal injury, proliferation, oligodendrocytes, caspase-3, PPARgamma.
Neuroprotection and neurorestauration: angiotensin receptor blockers, melatonin, ApoE genotype, sartans, inhaled nitric oxide, candesartan, telmisartan, antisense therapy.
Brain-periphery axis: hepatic inflammation, acute phase proteins, serum amyloid A, systemic inflammation, brain-liver axis, brain-gut axis, microbiome, Brain-Speen axis, Brain-Kidney axis.
Areas of expertise:
- Cerebral ischemia and traumatic brain injury
- Neuroinflammation and neurodegeneration
- Sex and gender differences in response to brain damage
- Brain-Liver axis ~ Brain-gut-microbiome axis
- Glia activation
- Neuroprotection and Neurorestoration
Sonia Villapol, Ph.D.
My scientific research has focused on elucidating the basic mechanisms and processes that occur after different types of brain injuries, including apoptosis, inflammation, neurogenesis or glial activation. My future research plan is fueled by my motivation of investigating the distinct, intricate aspects of the contribution of peripheral signals and microbiome to brain pathology.
I'm very passionate about mentoring and teaching those that are just starting their career in science; it is one of the most rewarding things I've experienced as a scientist. During my time as Assistant Professor at Georgetown University, I have mentored 19 students; 4 undergrads, 2 medical students, 4 Ph.D. students, 2 postdocs, and 8 master students (Biochemistry and Physiology programs).