About Villapol Lab
The Villapol laboratory studies the inflammatory and neurodegenerative mechanisms triggered after brain trauma or stroke in a sex dependent manner. Her laboratory is also investigating the contribution of peripheral signals and the gut microbiome to brain pathology. Her lab pursues novel neurorestorative treatments for brain recovery through the lens of the periphery.
Texas Medical center
Our lab members
Dr. Sirena Soriano joins the Villapol Lab as a Postdoctoral Fellow in April, 2019.
Dr. Manoj Dandekar joins the Villapol Lab as a Research Associate in March 2019.
Dr. Villapol was delighted to speak at Mission Connect Meeting today @McGovernMed @TIRRF presenting my lab at the Center for Neuroregeneration.Looking forward to new collaborations @TXMedCenter #Neurorestoration #Neuroprotection #BrainInjury #TBI #stroke #GUTbrainAxis #Periphery #Microbiome
Our first MICROBIOME study “Traumatic brain injury in mice induces acute bacterial dysbiosis within the fecal microbiome”, was published in Frontiers in Immunology.
Dr. Villapol was invited to give a seminar at @VCU Department of Anatomy and #Neurobiology, Dr. Andrew Ottens. Thanks faculty, Ph.D. candidates, and Dr. Povlishock for your hospitality!! #Neurotrauma #TBI #proteomics #brainInjury #Neuroinflammation #Glia
Shashi Krishnamurthy presented a poster on Mission Connect Meeting, Houston, Nov 30.
Sonia Villapol, Ph.D.
About Dr. Sonia Villapol
Dr. Sonia Villapol is an Assistant Professor of Neurosurgery at the Center for Neuroregeneration, HMRI.
Her scientific research has focused on elucidating the basic mechanisms and processes that occur after different types of brain injuries, including apoptosis, inflammation, neurogenesis or glial activation. Our future research plan is fueled by my motivation of investigating the distinct, intricate aspects of the contribution of peripheral signals and microbiome to brain pathology.
Areas of expertise:
- Cerebral ischemia and traumatic brain injury
- Neuroinflammation and neurodegeneration
- Sex and gender differences in response to brain damage
- Brain-Periphery axis
- Brain-gut-microbiome axis
- Neuroprotection and Neurorestoration
Brain damage: excitotoxicity, cerebral ischemia, stroke, traumatic brain injury, neonatal and adult.
Neuroinflammation: microglia activation, astrogliosis, cytokines, oxidative stress, gliosis, sex-differences, trauma, macrophages, cerebral blood flow, cerebral edema, hypertension, vasculature, glial scar, TGFbeta, smad3, NOS
Neurodegeneration and neurogenesis: apoptosis, necrosis, neurorestoration, neuronal injury, proliferation, oligodendrocytes, caspase-3, PPARgamma.
Neuroprotection and neurorestauration: angiotensin receptor blockers, melatonin, ApoE genotype, sartans, inhaled nitric oxide, candesartan, telmisartan, antisense therapy.
Brain-periphery axis: hepatic inflammation, acute phase proteins, serum amyloid A, systemic inflammation, brain-liver axis, brain-gut axis, microbiome, Brain-Speen axis, Brain-Kidney axis.
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