Our Goal is to find new treatments to restore and protect the injured brain
— Sonia Villapol, Ph.D.

Pubmed search for Villapol Lab papers

Peer-Reviewed Research Articles and reviews

Citations: 1048    h-index: 20    i10-index: 28

Citations: 1048

h-index: 20

i10-index: 28



  1. Serum Amyloid A Protein as a Potential Biomarker for Severity and Acute Outcome in Traumatic Brain Injury. E Wicker, L Benton, K George, W Furlow, S Villapol. BioMed Research International 2019


  1. Traumatic brain injury in mice induces acute bacterial dysbiosis within the fecal microbiome. Treangen TJ., Wagner J, Burns MP., Villapol S. Frontiers in Immunology, 9:2757. PDF

  2. Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury. Main BS, Villapol S, Sloley SS, Barton DJ, Parsadanian M, Agbaegbu C, Stefos K, McCann MS, Washington PM, Rodriguez OC, Burns MP. Mol Neurodegener. 2018 Apr 4;13(1):17.

  3. Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics. Lorenzo Bozzelli P, Alaiyed S, Kim E, Villapol S, Conant K. Neural Plast. 2018 Feb 4;2018:5735789.

  4.  Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain. Lanfranco MF, Mocchetti I, Burns MP, Villapol S. Front Neuroanat. 2018 Jan 12;11:137.

  5.  Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation. Villapol S. Cell Mol Neurobiol. 2018 Jan;38(1):121-132. Review. PMID:28975471


  1. Combination of Fluorescent in situ Hybridization (FISH) and Immunofluorescence Imaging for Detection of Cytokine Expression in Microglia/Macrophage Cells. Fe Lanfranco M, Loane DJ, Mocchetti I, Burns MP, Villapol S. Bio Protoc. 2017 Nov 20;7(22). pii: e2608. doi: 10.21769/BioProtoc.2608. PMID:29238736

  2. Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice. Zhou J, Burns MP, Huynh L, Villapol S, Taub DD, Saavedra JM, Blackman MR. Front Endocrinol (Lausanne). 2017 Sep 11;8:231. doi: 10.3389/fendo.2017.00231. eCollection 2017. PMID:28955302

  3. Sexual dimorphism in the inflammatory response to traumatic brain injury. Villapol S, Loane DJ, Burns MP. Glia. 2017 Sep;65(9):1423-1438. doi: 10.1002/glia.23171. Epub 2017 Jun 13. PMID: 28608978

  4. Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. Neustadtl AL, Winston CN, Parsadanian M, Main BS, Villapol S, Burns MP. Neuroreport. 2017 Jul 5;28(10):618-624. doi: 10.1097/WNR.0000000000000811. PMID: 28542068

  5. A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury. Main BS, Sloley SS, Villapol S, Zapple DN, Burns MP. J Vis Exp. 2017 Jun 20;(124). doi: 10.3791/55713. PMID: 28654066

  6. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury. Barrett JP, Henry RJ, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ. J Neuroinflammation. 2017 Mar 24;14(1):65. doi: 10.1186/s12974-017-0843-4. PMID:28340575

  7. Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin. De Magalhaes Filho CD, Kappeler L, Dupont J, Solinc J, Villapol S, Denis C, Nosten-Bertrand M, Billard JM, Blaise A, Tronche F, Giros B, Charriaut-Marlangue C, Aïd S, Le Bouc Y, Holzenberger M. J Cereb Blood Flow Metab. 2017 Feb;37(2):396-412. doi: 10.1177/0271678X15626718. Epub 2016 Jul 20. PMID:26762506


  1. Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1. Allen M, Ghosh S, Ahern GP, Villapol S, Maguire-Zeiss KA, Conant K. Sci Rep. 2016 Oct 20;6:35497. doi: 10.1038/srep35497. PMID:27762280

  2.  Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Winston CN, Noël A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E, Burns MP. Am J Pathol. 2016 Mar;186(3):552-67. doi: 10.1016/j.ajpath.2015.11.006. Epub 2016 Feb 5. PMID:26857506

  3.  Consequences of hepatic damage after traumatic brain injury: current outlook and potential therapeutic targets. Villapol S. Neural Regen Res. 2016 Feb;11(2):226-7. doi: 10.4103/1673-5374.177720. No abstract available. PMID:27073366

  4.  Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy? Washington PM, Villapol S, Burns MP. Exp Neurol. 2016 Jan;275 Pt 3:381-388. doi: 10.1016/j.expneurol.2015.06.015. Epub 2015 Jun 16. Review. PMID:26091850


  1. Neurorestoration after traumatic brain injury through angiotensin II receptor blockage. Villapol S, Balarezo MG, Affram K, Saavedra JM, Symes AJ. Brain. 2015 Nov;138(Pt 11):3299-315. doi: 10.1093/brain/awv172. Epub 2015 Jun 26. PMID:26115674

  2. Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan. Villapol S, Kryndushkin D, Balarezo MG, Campbell AM, Saavedra JM, Shewmaker FP, Symes AJ. Am J Pathol. 2015 Oct;185(10):2641-52. doi: 10.1016/j.ajpath.2015.06.016. PMID: 26435412

  3. Neuroprotective effects of angiotensin receptor blockers. Villapol S, Saavedra JM. Am J Hypertens. 2015 Mar;28(3):289-99. doi: 10.1093/ajh/hpu197. Epub 2014 Oct 31. Review. PMID: 25362113


  1. Temporal dynamics of cerebral blood flow, cortical damage, apoptosis, astrocyte-vasculature interaction and astrogliosis in the pericontusional region after traumatic brain injury. Villapol S, Byrnes KR, Symes AJ. Front Neurol. 2014 Jun 4;5:82. doi: 10.3389/fneur.2014.00082. eCollection 2014. PMID: 24926283

  2. Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice. Susarla BT, Villapol S, Yi JH, Geller HM, Symes AJ. ASN Neuro. 2014 May 8;6(3):159-70. doi: 10.1042/AN20130034. PMID:24670035


  1. Smad3 deficiency increases cortical and hippocampal neuronal loss following traumatic brain injury. Villapol S, Wang Y, Adams M, Symes AJ. Exp Neurol. 2013 Dec;250:353-65. doi: 10.1016/j.expneurol.2013.10.008. Epub 2013 Oct 9. PMID: 24120438

  2. Commercially available angiotensin II At₂ receptor antibodies are nonspecific. Hafko R, Villapol S, Nostramo R, Symes A, Sabban EL, Inagami T, Saavedra JM. PLoS One. 2013 Jul 1;8(7):e69234. doi: 10.1371/journal.pone.0069234. Print 2013. PMID: 23840911

  3. TGF-β superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury. Logan TT, Villapol S, Symes AJ. PLoS One. 2013;8(3):e59250. doi: 10.1371/journal.pone.0059250. Epub 2013 Mar 21. PMID:23555640


  1.  Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. Charriaut-Marlangue C, Bonnin P, Gharib A, Leger PL, Villapol S, Pocard M, Gressens P, Renolleau S, Baud O. Stroke. 2012 Nov;43(11):3078-84. doi: 10.1161/STROKEAHA.112.664243. Epub 2012 Sep 4. PMID:22949477

  2.  Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Villapol S, Yaszemski AK, Logan TT, Sánchez-Lemus E, Saavedra JM, Symes AJ. Neuropsychopharmacology. 2012 Dec;37(13):2817-29. doi: 10.1038/npp.2012.152. Epub 2012 Aug 15. PMID:22892395

  3.  Dual action of NO synthases on blood flow and infarct volume consecutive to neonatal focal cerebral ischemia. Bonnin P, Leger PL, Villapol S, Deroide N, Gressens P, Pocard M, Renolleau S, Baud O, Charriaut-Marlangue C. Exp Neurol. 2012 Jul;236(1):50-7. doi: 10.1016/j.expneurol.2012.04.001. Epub 2012 Apr 12. PMID:22531298

    2011 - 2006

  1. Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. Villapol S, Fau S, Renolleau S, Biran V, Charriaut-Marlangue C, Baud O. Pediatr Res. 2011 Jan;69(1):51-5. doi: 10.1203/PDR.0b013e3181fcb40b. PMID:20856166

  2. Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain. Villapol S, Bonnin P, Fau S, Baud O, Renolleau S, Charriaut-Marlangue C. Am J Pathol. 2009 Nov;175(5):2111-20. doi: 10.2353/ajpath.2009.090257. Epub 2009 Oct 8. PMID:19815715

  3. Astrocytic demise in the developing rat and human brain after hypoxic-ischemic damage. Gelot A, Villapol S, Billette de Villemeur T, Renolleau S, Charriaut-Marlangue C. Dev Neurosci. 2009;31(5):459-70. doi: 10.1159/000232564. Epub 2009 Aug 11. PMID: 19672074

  4. Astrocyte responses after neonatal ischemia: the yin and the yang. Villapol S, Gelot A, Renolleau S, Charriaut-Marlangue C. Neuroscientist. 2008 Aug;14(4):339-44. doi: 10.1177/1073858408316003. Epub 2008 Jul 8. Review. PMID: 18612085

  5.  Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain. Villapol S, Acarin L, Faiz M, Castellano B, Gonzalez B. Neuroscience. 2008 Apr 22;153(1):108-19. doi: 10.1016/j.neuroscience.2008.01.054. Epub 2008 Feb 14. PMID: 18358624

  6. Distinct spatial and temporal activation of caspase pathways in neurons and glial cells after excitotoxic damage to the immature rat brain. Villapol S, Acarin L, Faiz M, Castellano B, Gonzalez B. J Neurosci Res. 2007 Dec;85(16):3545-56. PMID:17668855

  7.  Bilateral changes after neonatal ischemia in the P7 rat brain. Spiegler M, Villapol S, Biran V, Goyenvalle C, Mariani J, Renolleau S, Charriaut-Marlangue C. J Neuropathol Exp Neurol. 2007 Jun;66(6):481-90. Erratum in: J Neuropathol Exp Neurol. 2007 Jul;66(7):673. PMID: 17549008

  8. Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation. Acarin L, Villapol S, Faiz M, Rohn TT, Castellano B, González B. Glia. 2007 Jul;55(9):954-65. PMID:17487878

  9. Antioxidant Cu/Zn SOD: expression in postnatal brain progenitor cells. Faiz M, Acarin L, Peluffo H, Villapol S, Castellano B, González B. Neurosci Lett. 2006 Jun 19;401(1-2):71-6. Epub 2006 Mar 29. PMID: 16567040